Ontology highlight
ABSTRACT:
SUBMITTER: Carcamo-Orive I
PROVIDER: S-EPMC5669062 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Carcamo-Orive Ivan I Huang Ngan F NF Quertermous Thomas T Knowles Joshua W JW
Arteriosclerosis, thrombosis, and vascular biology 20170720 11
Insulin resistance leads to a number of metabolic and cellular abnormalities including endothelial dysfunction that increase the risk of vascular disease. Although it has been particularly challenging to study the genetic determinants that predispose to abnormal function of the endothelium in insulin-resistant states, the possibility of deriving endothelial cells from induced pluripotent stem cells generated from individuals with detailed clinical phenotyping, including accurate measurements of ...[more]