Ontology highlight
ABSTRACT:
SUBMITTER: Fraser JF
PROVIDER: S-EPMC5669346 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Fraser Justin F JF Maniskas Michael M Trout Amanda A Lukins Doug D Parker Lindsey L Stafford W Lane WL Alhajeri Abdulnasser A Roberts Jill J Bix Gregory J GJ
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170421 11
Large vessel ischemic stroke represents the most disabling subtype. While t-PA and endovascular thrombectomy can recanalize the occluded vessel, good clinical outcomes are not uniformly achieved. We propose that supplementing endovascular thrombectomy with superselective intra-arterial (IA) verapamil immediately following recanalization could be safe and effective. Verapamil, a calcium channel blocker, has been shown to be an effective IA adjunct in a pre-clinical mouse focal ischemia model. To ...[more]