Ontology highlight
ABSTRACT:
SUBMITTER: Kuroda M
PROVIDER: S-EPMC5669554 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Kuroda Mariko M Muramatsu Rieko R Maedera Noriko N Koyama Yoshihisa Y Hamaguchi Machika M Fujimura Harutoshi H Yoshida Mari M Konishi Morichika M Itoh Nobuyuki N Mochizuki Hideki H Yamashita Toshihide T
The Journal of clinical investigation 20170821 9
Demyelination in the central nervous system (CNS) leads to severe neurological deficits that can be partially reversed by spontaneous remyelination. Because the CNS is isolated from the peripheral milieu by the blood-brain barrier, remyelination is thought to be controlled by the CNS microenvironment. However, in this work we found that factors derived from peripheral tissue leak into the CNS after injury and promote remyelination in a murine model of toxin-induced demyelination. Mechanistically ...[more]