Ontology highlight
ABSTRACT:
SUBMITTER: Heer FT
PROVIDER: S-EPMC5669632 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
eLife 20171010
Potassium channels are opened by ligands and/or membrane potential. In voltage-gated K<sup>+</sup> channels and the prokaryotic KcsA channel, conduction is believed to result from opening of an intracellular constriction that prevents ion entry into the pore. On the other hand, numerous ligand-gated K<sup>+</sup> channels lack such gate, suggesting that they may be activated by a change within the selectivity filter, a narrow region at the extracellular side of the pore. Using molecular dynamics ...[more]