Ontology highlight
ABSTRACT:
SUBMITTER: Shuang W
PROVIDER: S-EPMC5669943 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Shuang Wu W Hou Lili L Zhu Yan Y Li Qun Q Hu Wanglai W
Oncotarget 20170812 47
Taxol has been extensively used as an antineoplastic drug to treat human gastric cancer. However, the acquired drug resistance invariably develops and greatly limits the therapeutic efficacy of Taxol. Identification of the underlying resistance mechanisms may inform the development of new therapies of gastric cancers to Taxol treatment. Here we report that upregulation of Mcl-1 (Myeloid cell leukemia-1) confers acquired resistance to Taxol in human gastric cancer. Mcl-1 is shown to be stabilized ...[more]