Ontology highlight
ABSTRACT:
SUBMITTER: Borensztein M
PROVIDER: S-EPMC5670228 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Borensztein Maud M Okamoto Ikuhiro I Syx Laurène L Guilbaud Guillaume G Picard Christel C Ancelin Katia K Galupa Rafael R Diabangouaya Patricia P Servant Nicolas N Barillot Emmanuel E Surani Azim A Saitou Mitinori M Chen Chong-Jian CJ Anastassiadis Konstantinos K Heard Edith E
Nature communications 20171103 1
X-chromosome inactivation is established during early development. In mice, transcriptional repression of the paternal X-chromosome (Xp) and enrichment in epigenetic marks such as H3K27me3 is achieved by the early blastocyst stage. X-chromosome inactivation is then reversed in the inner cell mass. The mechanisms underlying Xp reactivation remain enigmatic. Using in vivo single-cell approaches (allele-specific RNAseq, nascent RNA-fluorescent in situ hybridization and immunofluorescence), we show ...[more]