Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Berezo T
PROVIDER: S-EPMC5670229 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Pérez-Berezo Teresa T Pujo Julien J Martin Patricia P Le Faouder Pauline P Galano Jean-Marie JM Guy Alexandre A Knauf Claude C Tabet Jean Claude JC Tronnet Sophie S Barreau Frederick F Heuillet Maud M Dietrich Gilles G Bertrand-Michel Justine J Durand Thierry T Oswald Eric E Cenac Nicolas N
Nature communications 20171103 1
Administration of the probiotic Escherichia coli strain Nissle 1917 (EcN) decreases visceral pain associated with irritable bowel syndrome. Mutation of clbA, a gene involved in the biosynthesis of secondary metabolites, including colibactin, was previously shown to abrogate EcN probiotic activity. Here, we show that EcN, but not an isogenic clbA mutant, produces an analgesic lipopeptide. We characterize lipoamino acids and lipopeptides produced by EcN but not by the mutant by online liquid chrom ...[more]