Ontology highlight
ABSTRACT:
SUBMITTER: Pantaleao TU
PROVIDER: S-EPMC5670274 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Pantaleão Thiago U TU Ferreira Andrea C F ACF Santos Maria C S MCS Figueiredo Álvaro S P ÁSP Louzada Ruy A N RAN Rosenthal Doris D Carvalho Denise P DP Corrêa da Costa Vânia M VM
Endocrine connections 20171101 8
Mercury seems to exert an inhibitory effect on deiodinases, but there are few studies using Thimerosal (TM) as the mercury source. We aimed to elucidate the effect of TM on thyroid hormones peripheral metabolism. Adult Wistar female rats received 0.25 µg or 250 µg TM/100 g BW, IM, twice a week, for a month. We evaluated serum total T<sub>3</sub> and T<sub>4</sub>, D1 activity using <sup>125</sup>I-rT<sub>3</sub> as tracer, and D2 activity using <sup>125</sup>I-T<sub>4</sub> NADPH oxidase activit ...[more]