Ontology highlight
ABSTRACT:
SUBMITTER: Yuan G
PROVIDER: S-EPMC5671725 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Yuan Gengyang G Jankins Tanner C TC Patrick Christopher G CG Philbrook Phaethon P Sears Olivia O Hatfield Stephen S Sitkovsky Michail M Vasdev Neil N Liang Steven H SH Ondrechen Mary Jo MJ Pollastri Michael P MP Jones Graham B GB
International journal of medicinal chemistry 20171019
Antagonism of the adenosine A<sub>2A</sub> receptor on T cells blocks the hypoxia-adenosinergic pathway to promote tumor rejection. Using an <i>in vivo</i> immunoassay based on the Concanavalin A mouse model, a series of A<sub>2A</sub> antagonists were studied and identified preladenant as a potent lead compound for development. Molecular modeling was employed to assist drug design and subsequent synthesis of analogs and those of tozadenant, including fluorinated polyethylene glycol PEGylated de ...[more]