Leukocyte telomere length and cardiovascular disease in African Americans: The Jackson Heart Study.

ABSTRACT:

Background and aims

In European descent populations, shorter leukocyte telomere length (LTL) has been associated with subclinical atherosclerosis, cardiovascular disease (CVD), and mortality, while longer LTL has been associated with greater left ventricular hypertrophy. We evaluated the relationship of LTL with subclinical cardiovascular disease indices and incident clinical events and mortality in African Americans (AAs).

Methods

Analyses were restricted to 2518 participants of the Jackson Heart Study (JHS) with LTL measured by Southern blot in baseline blood samples.

Results

Adjusting for established CVD risk factors, longer LTL was significantly associated with lower prevalence of coronary artery calcification (CAC) (odds ratio (OR) = 0.810) per 1 kb increase in L

SUBMITTER: Mwasongwe S 

PROVIDER: S-EPMC5671898 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature