Dietary adaptation of FADS genes in Europe varied across time and geography.
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ABSTRACT:
SUBMITTER: Ye K
PROVIDER: S-EPMC5672832 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Dietary adaptation of FADS genes in Europe varied across time and geography.
Ye Kaixiong K Gao Feng F Wang David D Bar-Yosef Ofer O Keinan Alon A
Nature ecology & evolution 20170526
Fatty acid desaturase (FADS) genes encode rate-limiting enzymes for the biosynthesis of omega-6 and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs). This biosynthesis is essential for individuals subsisting on LCPUFA-poor diets (for example, plant-based). Positive selection on FADS genes has been reported in multiple populations, but its cause and pattern in Europeans remain unknown. Here we demonstrate, using ancient and modern DNA, that positive selection acted on the same FADS varian ...[more]
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