Separase is a marker for prognosis and mitotic activity in breast cancer.

ABSTRACT:

Background

Cancer cell proliferation is a critical feature in classifying and predicting the outcome of breast carcinoma. Separase has a central role in cell cycle progression in unleashing sister-chromatids at anaphase onset. Abnormally functioning separase is known to lead to chromosomal instability.

Methods

The study comprises 349 breast carcinoma patients treated in Central Hospital of Central Finland. The prognostic value, role as a proliferation marker and regulatory interactions of separase are evaluated by immunohistochemical and double- and triple-immunofluorescence (IF) detections based on complete clinical data and >22-year follow-up of the patient material.

Results

In our material, abnormal separase expression predicted doubled risk of breast cancer death

SUBMITTER: Gurvits N 

PROVIDER: S-EPMC5672940 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature