Metabolomic Alterations Associated with Cause of CKD.

ABSTRACT:

Background and objectives

Causes of CKD differ in prognosis and treatment. Metabolomic indicators of CKD cause may provide clues regarding the different physiologic processes underlying CKD development and progression.

Design, setting, participants & measurements

Metabolites were quantified from serum samples of participants in the Modification of Diet in Renal Disease (MDRD) Study, a randomized controlled trial of dietary protein restriction and BP control, using untargeted reverse phase ultraperformance liquid chromatography tandem mass spectrometry quantification. Known, nondrug metabolites (n=687) were log-transformed and analyzed to discover associations with CKD cause (polycystic kidney disease, glomerular disease, and other cause). Discovery was performed in St

SUBMITTER: Grams ME 

PROVIDER: S-EPMC5672969 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature