Ontology highlight
ABSTRACT:
SUBMITTER: Yuan AH
PROVIDER: S-EPMC5673250 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Yuan Andy H AH Hochschild Ann A
Molecular microbiology 20091015 4
The bacteriophage T4 AsiA protein is a bifunctional regulator that inhibits transcription from the major class of bacterial promoters and also serves as an essential co-activator of transcription from T4 middle promoters. AsiA binds the primary s factor in Escherichia coli, sigma(70), and modifies the promoter recognition properties of the sigma(70)-containing RNA polymerase(RNAP) holoenzyme. In its role as co-activator, AsiA directs RNAP to T4 middle promoters in the presence of the T4-encoded ...[more]