Ontology highlight
ABSTRACT:
SUBMITTER: Dasa SSK
PROVIDER: S-EPMC5673558 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Dasa Siva Sai Krishna SSK Suzuki Ryo R Mugler Emily E Chen Lanlin L Jansson-Löfmark Rasmus R Michaëlsson Erik E Lindfors Lennart L Klibanov Alexander L AL French Brent A BA Kelly Kimberly A KA
Nanomedicine : nanotechnology, biology, and medicine 20170725 8
Liposome-based drug formulations represent an exciting avenue of research as they increase efficacy to toxicity ratios. Current formulations rely on passive accumulation to the disease site where drug is taken up by the cells. Ligand mediated targeting increases the net accumulation of liposomes, however, an unexplored benefit is to potentially refine pharmacodynamics (PD) of a drug specifically to different cell types within diseased tissue. As a model system, we engineered cardiomyocyte- (I-1) ...[more]