Ontology highlight
ABSTRACT:
SUBMITTER: Crawford JE
PROVIDER: S-EPMC5673686 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Crawford Jacob E JE Amaru Ricardo R Song Jihyun J Julian Colleen G CG Racimo Fernando F Cheng Jade Yu JY Guo Xiuqing X Yao Jie J Ambale-Venkatesh Bharath B Lima João A JA Rotter Jerome I JI Stehlik Josef J Moore Lorna G LG Prchal Josef T JT Nielsen Rasmus R
American journal of human genetics 20171101 5
The increase in red blood cell mass (polycythemia) due to the reduced oxygen availability (hypoxia) of residence at high altitude or other conditions is generally thought to be beneficial in terms of increasing tissue oxygen supply. However, the extreme polycythemia and accompanying increased mortality due to heart failure in chronic mountain sickness most likely reduces fitness. Tibetan highlanders have adapted to high altitude, possibly in part via the selection of genetic variants associated ...[more]