A vital sugar code for ricin toxicity.
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ABSTRACT:
SUBMITTER: Taubenschmid J
PROVIDER: S-EPMC5674155 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
A vital sugar code for ricin toxicity.
Taubenschmid Jasmin J Stadlmann Johannes J Jost Markus M Klokk Tove Irene TI Rillahan Cory D CD Leibbrandt Andreas A Mechtler Karl K Paulson James C JC Jude Julian J Zuber Johannes J Sandvig Kirsten K Elling Ulrich U Marquardt Thorsten T Thiel Christian C Koerner Christian C Penninger Josef M JM
Cell research 20170919 11
Ricin is one of the most feared bioweapons in the world due to its extreme toxicity and easy access. Since no antidote exists, it is of paramount importance to identify the pathways underlying ricin toxicity. Here, we demonstrate that the Golgi GDP-fucose transporter Slc35c1 and fucosyltransferase Fut9 are key regulators of ricin toxicity. Genetic and pharmacological inhibition of fucosylation renders diverse cell types resistant to ricin via deregulated intracellular trafficking. Importantly, c ...[more]
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