Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Wilhite R
PROVIDER: S-EPMC5674277 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.
Wilhite Rodger R Sage Jessica M JM Bouzid Abdurrahman A Primavera Tyler T Agbas Abdulbaki A
Future science OA 20170816 4
<h4>Aim</h4>Alzheimer's disease (AD) and other forms of dementia create a noncurable disease population in world's societies. To develop a blood-based biomarker is important so that the remedial or disease-altering therapeutic intervention for AD patients would be available at the early stage.<h4>Materials & methods</h4>TDP-43 levels were analyzed in postmortem brain tissue and platelets of AD and control subjects.<h4>Results</h4>We observed an increased TDP-43 (<60%) in postmortem AD brain regi ...[more]
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