Ontology highlight
ABSTRACT:
SUBMITTER: Rausch V
PROVIDER: S-EPMC5674747 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Rausch Valentin V Krieg Andreas A Camps Jordi J Behrens Bianca B Beier Manfred M Wangsa Darawalee D Heselmeyer-Haddad Kerstin K Baldus Stephan E SE Knoefel Wolfram T WT Ried Thomas T Stoecklein Nikolas H NH
BMC research notes 20171106 1
<h4>Background</h4>Mortality rates of pancreatic cancer remain high, which is mainly due to advanced disease and metastasis. We hypothesized that genomic copy number alterations are enriched in metastatic cells compared to autologous primary tumors, which may inform on cancer-related pathways possibly serving as potential targets for specific therapies. We investigated 18 pancreatic ductal adenocarcinomas, including 39 lymph node and 5 distant metastases after surgical resection. Analysis was pe ...[more]