Alzheimer's disease disrupts alpha and beta-band resting-state oscillatory network connectivity.

ABSTRACT:

Objective

Neuroimaging studies in Alzheimer's disease (AD) yield conflicting results due to selective investigation. We conducted a comprehensive magnetoencephalography study of connectivity changes in AD and healthy ageing in the resting-state.

Methods

We performed a whole-brain, source-space assessment of oscillatory neural signalling in multiple frequencies comparing AD patients, elderly and young controls. We compared eyes-open and closed group oscillatory envelope activity in networks obtained through temporal independent component analysis, and calculated whole-brain node-based amplitude and phase connectivity.

Results

In bilateral parietotemporal areas, oscillatory envelope amplitude increased with healthy ageing, whereas both local amplitude and node-to-global

SUBMITTER: Koelewijn L 

PROVIDER: S-EPMC5674981 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature