Antipsychotic-induced Hdac2 transcription via NF-?B leads to synaptic and cognitive side effects.
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ABSTRACT:
SUBMITTER: Ibi D
PROVIDER: S-EPMC5675106 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects.
Ibi Daisuke D de la Fuente Revenga Mario M Kezunovic Nebojsa N Muguruza Carolina C Saunders Justin M JM Gaitonde Supriya A SA Moreno José L JL Ijaz Maryum K MK Santosh Vishaka V Kozlenkov Alexey A Holloway Terrell T Seto Jeremy J García-Bea Aintzane A Kurita Mitsumasa M Mosley Grace E GE Jiang Yan Y Christoffel Daniel J DJ Callado Luis F LF Russo Scott J SJ Dracheva Stella S López-Giménez Juan F JF Ge Yongchao Y Escalante Carlos R CR Meana J Javier JJ Akbarian Schahram S Huntley George W GW González-Maeso Javier J
Nature neuroscience 20170807 9
Antipsychotic drugs remain the standard for schizophrenia treatment. Despite their effectiveness in treating hallucinations and delusions, prolonged exposure to antipsychotic medications leads to cognitive deficits in both schizophrenia patients and animal models. The molecular mechanisms underlying these negative effects on cognition remain to be elucidated. Here we demonstrate that chronic antipsychotic drug exposure increases nuclear translocation of NF-κB in both mouse and human frontal cort ...[more]
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