Ontology highlight
ABSTRACT:
SUBMITTER: Hartley CJ
PROVIDER: S-EPMC5675407 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Hartley Carol J CJ French Nigel G NG Scoble Judith A JA Williams Charlotte C CC Churches Quentin I QI Frazer Andrew R AR Taylor Matthew C MC Coia Greg G Simpson Gregory G Turner Nicholas J NJ Scott Colin C
PloS one 20171107 11
Carbon-carbon bond formation is one of the most challenging reactions in synthetic organic chemistry, and aldol reactions catalysed by dihydroxyacetone phosphate-dependent aldolases provide a powerful biocatalytic tool for combining C-C bond formation with the generation of two new stereo-centres, with access to all four possible stereoisomers of a compound. Dihydroxyacetone phosphate (DHAP) is unstable so the provision of DHAP for DHAP-dependent aldolases in biocatalytic processes remains compl ...[more]