Ontology highlight
ABSTRACT:
SUBMITTER: Wingerath J
PROVIDER: S-EPMC5675480 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20170720 11
Successful vaccination against cancer and infectious diseases relies on the induction of adaptive immune responses that induce high-titer antibodies or potent cytoxic T cell responses. In contrast to humoral vaccines, the amplification of cellular immune responses is often hampered by anti-vector immunity that either pre-exists or develops after repeated homologous vaccination. Replication-defective lymphocytic choriomeningitis virus (LCMV) vectors represent a novel generation of vaccination vec ...[more]