Ontology highlight
ABSTRACT:
SUBMITTER: Zhou H
PROVIDER: S-EPMC5675595 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Zhou Hao H Bulek Katarzyna K Li Xiao X Herjan Tomasz T Yu Minjia M Qian Wen W Wang Han H Zhou Gao G Chen Xing X Yang Hui H Hong Lingzi L Zhao Junjie J Qin Luke L Fukuda Koichi K Flotho Annette A Gao Ji J Dongre Ashok A Carman Julie A JA Kang Zizhen Z Su Bing B Kern Timothy S TS Smith Jonathan D JD Hamilton Thomas A TA Melchior Frauke F Fox Paul L PL Li Xiaoxia X
eLife 20171009
Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 engagement promotes nuclear localization of IRAK2 to facilitate nuclear export of a specific subset of inflammation-related mRNAs for translation in murine macrophages. IRAK2 kinase activity is required for LPS-induced RanBP2-mediated IRAK2 sumoylatio ...[more]