Dataset Information

Functional network analysis of gene-phenotype connectivity associated with temozolomide.

ABSTRACT:

Rationale

Glioma has a poor survival rate in patients even with aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for treating glioma, but TMZ treatment consistently leads to high resistance.

Aim

To investigate the underlying mechanisms of TMZ action with new therapeutic regimens in glioma.

Methods and results

The biological effects of TMZ mainly depend on the three following DNA repair systems: methylguanine methyltransferase (MGMT), mismatch repair (MMR) and base excision repair (BER). Based on related genes in these three systems, web-based tools containing data compiled from open-source databases, including DrugBank, STRING, WebGestalt and ClueGO, were queried, and five common genes along with the top fifteen pathways, including the glioma pathway, were identified. A genomic analysis of the six genes identified in the glioma pathway by cBioPortal indicated that TMZ might exert biological effects via interaction with the tumor protein P53(TP53) signaling axis. Finally, a survival analysis with the six genes in glioma cases (low-grade glioma and glioblastoma multiforme) was conducted using OncoLnc, which might provide directions for the future exploration of prognosis in glioma.

Conclusions

This study indicates that a functional network analysis resembles a "BioGPS", with the ability to draw a web-based scientific map that can productively and cost-effectively associate TMZ with its primary and secondary biological targets.

SUBMITTER: Shi J

PROVIDER: S-EPMC5675653 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Publications

Functional network analysis of gene-phenotype connectivity associated with temozolomide.

Shi Jia J Dong Bo B Zhou Peng P Guan Wei W Peng Ya Y

Oncotarget 20170912 50

<h4>Rationale</h4>Glioma has a poor survival rate in patients even with aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for treating glioma, but TMZ treatment consistently leads to high resistance.<h4>Aim</h4>To investigate the underlying mechanisms of TMZ action with new therapeutic regimens in glioma.<h4>Methods and results</h4>The biological effects of TMZ mainly depend on the three following DNA repair systems: methylguanine methyltransferase (MGMT), mismatch ...[more]

PMID: 29152101

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Dataset Information

Functional network analysis of gene-phenotype connectivity associated with temozolomide.

Rationale

Aim

Methods and results

Conclusions

Publications

Functional network analysis of gene-phenotype connectivity associated with temozolomide.

Similar Datasets

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