Ontology highlight
ABSTRACT:
SUBMITTER: Waickman AT
PROVIDER: S-EPMC5675755 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Waickman Adam T AT Ligons Davinna L DL Hwang SuJin S Park Joo-Young JY Lazarevic Vanja V Sato Noriko N Hong Changwan C Park Jung-Hyun JH
Cytokine 20170812
T cells are both producers and consumers of cytokines, and autocrine cytokine signaling plays a critical role in T cell immunity. IL-15 is a homeostatic cytokine for T cells that also controls inflammatory immune responses. An autocrine role of T cell-derived IL-15, however, remains unclear. Here we examined IL-15 expression and signaling upon effector T cell differentiation in mice, and, surprisingly, found that CD4 T cells did not express IL-15. CD4 T cells lacked Il15 gene reporter activity, ...[more]