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ABSTRACT:
SUBMITTER: Vargas E
PROVIDER: S-EPMC5676225 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Vargas Elizabeth E McNally Karen K Friedman Jacob A JA Cortes Daniel B DB Wang David Y DY Korf Ian F IF McNally Francis J FJ
Genetics 20170907 3
Trisomy and triploidy, defined as the presence of a third copy of one or all chromosomes, respectively, are deleterious in many species including humans. Previous studies have demonstrated that <i>Caenorhabditis elegans</i> with a third copy of the X chromosome are viable and fertile. However, the extra X chromosome was shown to preferentially segregate into the first polar body during oocyte meiosis to produce a higher frequency of euploid offspring than would be generated by random segregation ...[more]