Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC5676241 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Xu Zhiyuan Z Wu Chong C Wei Peng P Pan Wei W
Genetics 20170911 3
Two new gene-based association analysis methods, called <i>PrediXcan</i> and <i>TWAS</i> for GWAS individual-level and summary data, respectively, were recently proposed to integrate GWAS with eQTL data, alleviating two common problems in GWAS by boosting statistical power and facilitating biological interpretation of GWAS discoveries. Based on a novel reformulation of PrediXcan and TWAS, we propose a more powerful gene-based association test to integrate single set or multiple sets of eQTL data ...[more]