Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC5676595 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Protein & cell 20170921 11
TRPML1 channel is a non-selective group-2 transient receptor potential (TRP) channel with Ca<sup>2+</sup> permeability. Located mainly in late endosome and lysosome of all mammalian cell types, TRPML1 is indispensable in the processes of endocytosis, membrane trafficking, and lysosome biogenesis. Mutations of TRPML1 cause a severe lysosomal storage disorder called mucolipidosis type IV (MLIV). In the present study, we determined the cryo-electron microscopy (cryo-EM) structures of Mus musculus T ...[more]