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CXCL10/CXCR3 axis is associated with disease activity and the development of mucocutaneous lesions in patients with Behcet's disease.


ABSTRACT: The objective of this study was to investigate CXC chemokines and its receptor in patients with Behcet's disease (BD) and their associations with disease activity. Blood samples were collected from 109 BD patients and 36 age- and sex-matched healthy controls (HCs). Twenty-two follow-up blood samples were collected in BD patients. Serum CXC chemokines (CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13 and CXCL16) and cell surface marker expression (CD3, CD4 and CXCR3) in peripheral blood mononuclear cells (PBMCs) were assayed. Clinical features including disease activity were evaluated at the time of blood collection. CXCR3 expression in skin and intestinal lesions from BD patients and HCs was assessed via immunohistochemistry. Serum CXCL10 levels were correlated with disease activity in terms of Behçet's Disease Current Activity Form (BDCAF) (p?

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC5677118 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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CXCL10/CXCR3 axis is associated with disease activity and the development of mucocutaneous lesions in patients with Behçet's disease.

Lee Sang Jin SJ   Kang Shin Eui SE   Kang Eun Ha EH   Choi Byoong Yong BY   Masek-Hammerman Katherine K   Syed Jameel J   Zhan Yutian Y   Neff-Phillips Kathleen K   Park Jin Kyun JK   Lee Eun Young EY   Lee Eun Bong EB   Song Yeong Wook YW  

Scientific reports 20171107 1


The objective of this study was to investigate CXC chemokines and its receptor in patients with Behcet's disease (BD) and their associations with disease activity. Blood samples were collected from 109 BD patients and 36 age- and sex-matched healthy controls (HCs). Twenty-two follow-up blood samples were collected in BD patients. Serum CXC chemokines (CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13 and CXCL16) and cell surface marker expression (CD3, CD4 and CXCR3) in peripheral blood mononuclear ce  ...[more]

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