Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC5677365 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
eLife 20171013
Histone tail modifications can greatly influence chromatin-associated processes. Asymmetrically modified nucleosomes exist in multiple cell types, but whether modifications on both sister histones contribute equally to chromatin dynamics remains elusive. Here, we devised a bivalent nucleosome system that allowed for the constitutive assembly of asymmetrically modified sister histone H3s in nucleosomes in <i>Saccharomyces cerevisiae</i>. The sister H3K36 methylations independently affected crypti ...[more]