Targeting inflammation for the treatment of alcoholic liver disease.
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ABSTRACT:
SUBMITTER: Xu MJ
PROVIDER: S-EPMC5677537 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Targeting inflammation for the treatment of alcoholic liver disease.
Xu Ming-Jiang MJ Zhou Zhou Z Parker Richard R Gao Bin B
Pharmacology & therapeutics 20170619
Alcoholic liver disease (ALD) is a leading cause of chronic liver disease with a wide spectrum of manifestations including simple steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Liver injury in ALD is caused by chronic inflammation, which has been actively investigated as a therapeutic target for the treatment of ALD for over the last four decades. In this review, we summarize a wide variety of inflammatory mediators that have been shown to contribute to the pathogenesis o ...[more]
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