Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC5677551 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Liu Lucy L MacKenzie Kevin R KR Putluri Nagireddy N Maletić-Savatić Mirjana M Bellen Hugo J HJ
Cell metabolism 20170928 5
Elevated reactive oxygen species (ROS) induce the formation of lipids in neurons that are transferred to glia, where they form lipid droplets (LDs). We show that glial and neuronal monocarboxylate transporters (MCTs), fatty acid transport proteins (FATPs), and apolipoproteins are critical for glial LD formation. MCTs enable glia to secrete and neurons to absorb lactate, which is converted to pyruvate and acetyl-CoA in neurons. Lactate metabolites provide a substrate for synthesis of fatty acids, ...[more]