Ontology highlight
ABSTRACT:
SUBMITTER: Cha BH
PROVIDER: S-EPMC5677560 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cha Byung-Hyun BH Shin Su Ryon SR Leijten Jeroen J Li Yi-Chen YC Singh Sonali S Liu Julie C JC Annabi Nasim N Abdi Reza R Dokmeci Mehmet R MR Vrana Nihal Engin NE Ghaemmaghami Amir M AM Khademhosseini Ali A Khademhosseini Ali A
Advanced healthcare materials 20170807 21
Adverse immune reactions prevent clinical translation of numerous implantable devices and materials. Although inflammation is an essential part of tissue regeneration, chronic inflammation ultimately leads to implant failure. In particular, macrophage polarity steers the microenvironment toward inflammation or wound healing via the induction of M1 and M2 macrophages, respectively. Here, this paper demonstrates that macrophage polarity within biomaterials can be controlled through integrin-mediat ...[more]