MiR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells.
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ABSTRACT:
SUBMITTER: Bartoszewski R
PROVIDER: S-EPMC5677561 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells.
Bartoszewski Rafal R Serocki Marcin M Janaszak-Jasiecka Anna A Bartoszewska Sylwia S Kochan-Jamrozy Kinga K Piotrowski Arkadiusz A Króliczewski Jarosław J Collawn James F JF
European journal of cell biology 20171013 8
The role of microRNAs in controlling angiogenesis is recognized as a promising therapeutic target in both cancer and cardiovascular disorders. However, understanding a miRNA's pleiotropic effects on angiogenesis is a limiting factor for these types of therapeutic approaches. Using genome-wide next-generation sequencing, we examined the role of an antiangiogenic miRNA, miR-200b, in primary human endothelial cells. The results indicate that miR-200b has complex effects on hypoxia-induced angiogene ...[more]
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