Ontology highlight
ABSTRACT:
SUBMITTER: Lahav D
PROVIDER: S-EPMC5677758 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20170929 40
Human nonlysosomal glucosylceramidase (GBA2) is one of several enzymes that controls levels of glycolipids and whose activity is linked to several human disease states. There is a major need to design or discover selective GBA2 inhibitors both as chemical tools and as potential therapeutic agents. Here, we describe the development of a fluorescence polarization activity-based protein profiling (FluoPol-ABPP) assay for the rapid identification, from a 350+ library of iminosugars, of GBA2 inhibito ...[more]