Ontology highlight
ABSTRACT:
SUBMITTER: Machida J
PROVIDER: S-EPMC5678204 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Human genome variation 20171109
It has been reported that dozens of WNT10A variants are associated with human isolated tooth agenesis, however, little is known about the precise phenotypes. In 50 Japanese patients with severe congenital tooth agenesis, we identified 11 patients with WNT10A variants. Comparing phenotypes between the tooth agenesis patients carrying the wild-type and variants of <i>WNT10A</i>, we revealed that the development of lateral incisors is relatively susceptive to insufficiency of WNT/β-catenin signalin ...[more]