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WNT10A variants isolated from Japanese patients with congenital tooth agenesis.

ABSTRACT: It has been reported that dozens of WNT10A variants are associated with human isolated tooth agenesis, however, little is known about the precise phenotypes. In 50 Japanese patients with severe congenital tooth agenesis, we identified 11 patients with WNT10A variants. Comparing phenotypes between the tooth agenesis patients carrying the wild-type and variants of WNT10A, we revealed that the development of lateral incisors is relatively susceptive to insufficiency of WNT/?-catenin signaling.

SUBMITTER: Machida J 

PROVIDER: S-EPMC5678204 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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WNT10A variants isolated from Japanese patients with congenital tooth agenesis.

Machida Junichiro J   Goto Hiroaki H   Tatematsu Tadashi T   Shibata Akio A   Miyachi Hitoshi H   Takahashi Katsu K   Izumi Hiroto H   Nakayama Atsuo A   Shimozato Kazuo K   Tokita Yoshihito Y  

Human genome variation 20171109

It has been reported that dozens of WNT10A variants are associated with human isolated tooth agenesis, however, little is known about the precise phenotypes. In 50 Japanese patients with severe congenital tooth agenesis, we identified 11 patients with WNT10A variants. Comparing phenotypes between the tooth agenesis patients carrying the wild-type and variants of <i>WNT10A</i>, we revealed that the development of lateral incisors is relatively susceptive to insufficiency of WNT/β-catenin signalin  ...[more]

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