Ontology highlight
ABSTRACT:
SUBMITTER: Takata H
PROVIDER: S-EPMC5678930 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Takata Hiroshi H Buranapraditkun Supranee S Kessing Cari C Fletcher James L K JL Muir Roshell R Tardif Virginie V Cartwright Pearline P Vandergeeten Claire C Bakeman Wendy W Nichols Carmen N CN Pinyakorn Suteeraporn S Hansasuta Pokrath P Kroon Eugene E Chalermchai Thep T O'Connell Robert R Kim Jerome J Phanuphak Nittaya N Robb Merlin L ML Michael Nelson L NL Chomont Nicolas N Haddad Elias K EK Ananworanich Jintanat J Trautmann Lydie L
Science translational medicine 20170201 377
CD8<sup>+</sup> T cells play a critical role in controlling HIV viremia and could be important in reducing HIV-infected cells in approaches to eradicate HIV. The simian immunodeficiency virus model provided the proof of concept for a CD8<sup>+</sup> T cell-mediated reservoir clearance but showed conflicting evidence on the role of these cells to eliminate HIV-infected cells. In humans, HIV-specific CD8<sup>+</sup> T cell responses have not been associated with a reduction of the HIV-infected cel ...[more]