OP449 inhibits breast cancer growth without adverse metabolic effects.
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ABSTRACT:
SUBMITTER: Shlomai G
PROVIDER: S-EPMC5678946 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
OP449 inhibits breast cancer growth without adverse metabolic effects.
Shlomai Gadi G Zelenko Zara Z Antoniou Irini Markella IM Stasinopoulos Marilyn M Tobin-Hess Aviva A Vitek Michael P MP LeRoith Derek D Gallagher Emily Jane EJ
Endocrine-related cancer 20171001 10
Hyperinsulinemia is associated with a decrease in breast cancer recurrence-free survival and overall survival. Inhibition of insulin receptor signaling is associated with glycemic dysregulation. SET is a direct modulator of PP2A, which negatively regulates the PI3K/AKT/mTOR pathway. OP449, a SET inhibitor, decreases AKT/mTOR activation. The effects of OP449 treatment on breast cancer growth in the setting of pre-diabetes, and its metabolic implications are currently unknown. We found that the vo ...[more]
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