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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.

ABSTRACT: Interleukin 2 (IL-2) promotes Foxp3+ regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1-dependent mechanism. However, once the immune response resolved, some Treg cells downregulated CD25, upregulated Bcl-6 and differentiated into TFR cells, which then migrated into the B cell follicles to prevent the expansion of self-reactive B cell clones. Thus, unlike its effects on conventional Treg cells, IL-2 inhibits TFR cell responses.

SUBMITTER: Botta D

PROVIDER: S-EPMC5679073 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.

Botta Davide D Fuller Michael J MJ Marquez-Lago Tatiana T TT Bachus Holly H Bradley John E JE Weinmann Amy S AS Zajac Allan J AJ Randall Troy D TD Lund Frances E FE León Beatriz B Ballesteros-Tato André A

Nature immunology 20170911 11

Interleukin 2 (IL-2) promotes Foxp3+ regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1-dependent ...[more]

PMID: 28892471

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