Ontology highlight
ABSTRACT:
SUBMITTER: Loskot SA
PROVIDER: S-EPMC5679227 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20170724 30
An enantioselective total synthesis of the norditerpenoid alkaloid nigelladine A is described. Strategically, the synthesis relies on a late-stage C-H oxidation of an advanced intermediate. While traditional chemical methods failed to deliver the desired outcome, an engineered cytochrome P450 enzyme was employed to effect a chemo- and regioselective allylic C-H oxidation in the presence of four oxidizable positions. The enzyme variant was readily identified from a focused library of three enzyme ...[more]