Ontology highlight
ABSTRACT:
SUBMITTER: Clay GM
PROVIDER: S-EPMC5679237 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Clay Gwendolyn M GM Valadares Diogo G DG Graff Joel W JW Ulland Tyler K TK Davis Richard E RE Scorza Breanna M BM Zhanbolat Bayan Sudan BS Chen Yani Y Sutterwala Fayyaz S FS Wilson Mary E ME
Journal of immunology (Baltimore, Md. : 1950) 20170920 8
The role of the nucleotide-binding domain and leucine-rich repeat containing receptor NLRP10 in disease is incompletely understood. Using three mouse strains lacking the gene encoding NLRP10, only one of which had a coincidental mutation in DOCK8, we documented a role for NLRP10 as a suppressor of the cutaneous inflammatory response to <i>Leishmania major</i> infection. There was no evidence that the enhanced local inflammation was due to enhanced inflammasome activity. NLRP10/DOCK8-deficient mi ...[more]