Planarian Epidermal Stem Cells Respond to Positional Cues to Promote Cell-Type Diversity.

ABSTRACT: Successful regeneration requires that progenitors of different lineages form the appropriate missing cell types. However, simply generating lineages is not enough. Cells produced by a particular lineage often have distinct functions depending on their position within the organism. How this occurs in regeneration is largely unexplored. In planarian regeneration, new cells arise from a proliferative cell population (neoblasts). We used the planarian epidermal lineage to study how the location of adult progenitor cells results in their acquisition of distinct functional identities. Single-cell RNA sequencing of epidermal progenitors revealed the emergence of distinct spatial identities as early in the lineage as the epidermal neoblasts, with further pre-patterning occurring in their post-mito

SUBMITTER: Wurtzel O 

PROVIDER: S-EPMC5679284 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature