Durability of immunity by hepatitis B vaccine in Japanese health care workers depends on primary response titers and durations.

ABSTRACT:

Background

Health care workers (HCWs) are frequently exposed to hepatitis B virus (HBV) infection. The efficacy and safety of immunization with the hepatitis B (HB) vaccine are well recognized, but the durability of immunity and need for booster doses in those with secondary vaccine response failure remains controversial.

Methods

This was a retrospective cohort study performed at Osaka University Hospital, Japan. We examined antibodies against HB surface antigen (anti-HBs) titers annually after immunization for previously non-immunized HCWs. Primary responders were categorized by their sero-positive durations as short responders (those whose anti-HBs titers declined to negative range within 3 years), and long responders (those who retained positive anti-HBs levels for 3 year

SUBMITTER: Yoshioka N 

PROVIDER: S-EPMC5679562 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature