Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.
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SUBMITTER: Davis JP
PROVIDER: S-EPMC5679656 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.
Davis James P JP Huyghe Jeroen R JR Locke Adam E AE Jackson Anne U AU Sim Xueling X Stringham Heather M HM Teslovich Tanya M TM Welch Ryan P RP Fuchsberger Christian C Narisu Narisu N Chines Peter S PS Kangas Antti J AJ Soininen Pasi P Ala-Korpela Mika M Kuusisto Johanna J Collins Francis S FS Laakso Markku M Boehnke Michael M Mohlke Karen L KL
PLoS genetics 20171030 10
Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established lo ...[more]
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