Ontology highlight
ABSTRACT:
SUBMITTER: Jin X
PROVIDER: S-EPMC5679732 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Jin Xun X Kim Leo J Y LJY Wu Qiulian Q Wallace Lisa C LC Prager Briana C BC Sanvoranart Tanwarat T Gimple Ryan C RC Wang Xiuxing X Mack Stephen C SC Miller Tyler E TE Huang Ping P Valentim Claudia L CL Zhou Qi-Gang QG Barnholtz-Sloan Jill S JS Bao Shideng S Sloan Andrew E AE Rich Jeremy N JN
Nature medicine 20171009 11
Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these histological features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile, and hypoxic regions showing a mesenchymal pattern. As these regions harbor glioma stem cells (GSCs), we investigated the epigenetic regulation of these two niches. Proneural, perivascular GSCs activated EZH2, whereas mesenchymal GSCs in hypoxic regions ...[more]