Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC5679747 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Chen Yi Y Zeng Xing X Huang Xuan X Serag Sara S Woolf Clifford J CJ Spiegelman Bruce M BM
Cell 20171005 4
Adrenergic stimulation promotes lipid mobilization and oxidation in brown and beige adipocytes, where the harnessed energy is dissipated as heat in a process known as adaptive thermogenesis. The signaling cascades and energy-dissipating pathways that facilitate thermogenesis have been extensively described, yet little is known about the counterbalancing negative regulatory mechanisms. Here, we identify a two-pore-domain potassium channel, KCNK3, as a built-in rheostat negatively regulating therm ...[more]