Ontology highlight
ABSTRACT:
SUBMITTER: Yoneda N
PROVIDER: S-EPMC5680189 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171109 1
Enantioselective approaches to synthesize six-membered oxacycles with multiple stereogenic centres are in high demand to enable the discovery of new therapeutic agents. Here we present a concise organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans involving simultaneous construction of two chiral centres, one of which is fully substituted. This method involves dynamic kinetic resolution of reversibly generated chiral cyanohydrins. A chi ...[more]