Ontology highlight
ABSTRACT:
SUBMITTER: Shin HT
PROVIDER: S-EPMC5680209 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171109 1
Accurate detection of genomic alterations using high-throughput sequencing is an essential component of precision cancer medicine. We characterize the variant allele fractions (VAFs) of somatic single nucleotide variants and indels across 5095 clinical samples profiled using a custom panel, CancerSCAN. Our results demonstrate that a significant fraction of clinically actionable variants have low VAFs, often due to low tumor purity and treatment-induced mutations. The percentages of mutations und ...[more]