Ontology highlight
ABSTRACT:
SUBMITTER: Finegersh A
PROVIDER: S-EPMC5680248 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Finegersh Andrey A Kulich Scott S Guo Theresa T Favorov Alexander V AV Fertig Elana J EJ Danilova Ludmila V LV Gaykalova Daria A DA Califano Joseph A JA Duvvuri Umamaheswar U
Scientific reports 20171109 1
ANO1 is a calcium-activated chloride channel that is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and other cancers. While ANO1 expression negatively correlates with survival in several cancers, its epigenetic regulation is poorly understood. We analyzed HNSCC samples from TCGA and a separate dataset of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) samples to identify differentially methylated regions. E6 and E7 transfected normal oral keratinocytes (NOK) were u ...[more]